For weekends, they're easy. A turtleneck sweater would be good, and a white tee and cool sneakers would be very chic and unfussy. But I think they're most fun (and unexpected) dressed up for work. You won't be able to wear these very often unless you want to encourage lame comments from your co-workers -- "Look, you're wearing your crazy pants again!"-- so pull them out sparingly and have fun building some really interesting looks.
the aforementioned crazy pants, a whimsical print in a modern cut // the best match for a bold print is a subtle print, like this great windowpane blouse // your favorite preppy blazer pulls everything together // more pattern-mixing with a graphic handbag // very tailored, very feminine heels make a casual pair of pants more elegant